The first thing to do with the letter
Identify whether HMRC has opened a formal enquiry into the return, is asking informal questions before deciding whether to open one, or has issued a formal Schedule 36 information notice. Each carries slightly different obligations and deadlines, and the letter should say which it is.
Note the deadline given for a response and diarise it immediately. HMRC generally allows a reasonable period, but this can feel short once you factor in gathering evidence from technical staff who may no longer all be with the company.
Do not respond immediately with a rushed or partial answer just to be seen to reply quickly; a well-prepared response within the deadline is far more valuable than a fast but weak one.

